No treatment recommendation can be made for adding naloxone to existing BLS practices for the BLS management of adults and children with suspected opioid-associated cardiac or respiratory arrest in the prehospital setting. Values, Preferences, and Task Force Insights All patients with suspected opioid-associated cardiac or respiratory arrest should receive standard BLS care, with or without the addition of naloxone. In making this recommendation, we place greater value on the potential for lives saved by recommending immediate BLS care and education, with or without naloxone, and lesser value on the costs associated with naloxone administration, distribution, or education.