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Ventilation Rate During Continuous Chest Compression

Question Type:
Intervention
Full Question:
Among adults with cardiac arrest with a secure airway receiving chest compressions (in any setting, and with standard tidal volume)  (P), does does a ventilation rate of 10 breaths/min  (I), compared with compared with any other ventilation rate  (C), change Survival with Favorable neurological/functional outcome at discharge, 30 days, 60 days, 180 days AND/OR 1 year, Survival only at discharge, 30 days, 60 days, 180 days AND/OR 1 year, ROSC (O)?
Consensus on Science:
We did not identify any evidence to address the critical outcomes of survival with favorable neurologic/functional outcome at discharge, 30 days, 60 days, 180 days and/or 1 year, survival at discharge, 30 days, 60 days, 180 days, and/or 1 year.We identified very-low-quality evidence (downgraded for very serious risk of bias and indirectness, and serious inconsistency and imprecision) from 10 animal studies(Sanders 2002, 553; Aufderheide 2004, S345; Aufderheide 2004, 1960; Yannopoulos 2004, 75; Yannopoulos 2006, 1444; Hayes 2007, 357; Cavus 2008, 118; Hwang 2008, 183; Gazmuri 2012, 259; Kill 2014, e89) and 1 human observational study(Abella 2005, 305-310) that does not enable us to estimate with confidence the effect of a ventilation rate of 10/min compared with any other rate for the important outcome of ROSC.
Treatment Recommendation:
We suggest a ventilation rate of 10 breaths/min in adults with cardiac arrest with a secure airway receiving continuous chest compressions (weak recommendation, very-low-quality evidence).Values, Preferences, and Task Force InsightsIn making this recommendation, we have valued the need to suggest a ventilation rate that is already in use. We note that the Australian and New Zealand Committee on Resuscitation (ANZCOR) currently recommends a ventilation rate of 6 to 10 breaths/min and would see no reason for this to change. We did not assess effect of tidal volume and any other ventilation variables during CPR and have therefore not addressed these in the treatment recommendation.
CoSTR Attachments:
Ventilation Rate after ROSC_3Jan2015_n.docx    
Ventilation rate during continuous chest compression_n.pptx    

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